20 The primary outcome variable was change in diastolic blood pressure from the baseline screening visits to the average of the midpoint and closing visits. Patients who withdrew from the study after the midpoint were included in the primary analysis. Blood pressure for each subject at baseline, midpoint https://datingranking.net/local-hookup/liverpool/, and closing was the average of nine measurements (three measurements on each of 3 days). The trial was designed to have at least 80% power to detect a change in blood pressure of 3 mm Hg diastolic with two-sided P<.05. The actual sensitivity of the trial for the effect of each cation combination was determined from the 95% confidence intervals of the differences in the blood pressure changes between supplement and placebo groups (for an example, see “Efficiency”). Multiple regression analyses determined the effect of each treatment compared with placebo using treatment group as an independent variable. Additional analyses were conducted on systolic blood pressure and on the changes at midpoint and closing, separately. Covariates were added to the multiple regression model to assess the effects of treatment in various subgroups of the patients, eg, baseline urinary electrolyte excretion. The model included treatment group, baseline urinary excretion, and the interaction term, treatment?urinary excretion. The effects of the treatments were also examined in subgroups with urinary electrolyte excretion levels above and below the median.
The newest 125 people who mode the primary data classification accomplished from the least the fresh new midpoint blood pressure level specifications. 7 patients was in fact withdrawn regarding demonstration due to an effective diastolic hypertension >102 mm Hg (eight prior to and 1 following midpoint proportions); dos of them was basically acquiring placebo, 3 was researching calcium supplements and potassium, 2 was basically receiving potassium and you can magnesium, and you will step 1 are getting calcium supplements and you will magnesium. Leer más