It is essential to remember that these nutrient translocations not merely mediate brand new mineral metabolic process represented within the Profile dos, but furthermore the cellular effects described inside the Desk step three.
Normal homeostatic controls holds solution profile, intracellular profile, and you may optimum mineral articles from inside the limbs. This control happens in the three big address areas, the newest bowels, kidney and you may bones, principally via the state-of-the-art integration out-of several hormones, parathyroid hormonal and nutritional D. An understanding of regular anatomy is necessary to truthfully recognize and eliminate disorders out of nutrient metabolic process and you will be briefly analyzed just before revealing the fresh new differential diagnosis and you can treatments for certain conditions.
A decrease in ionized calcium stimulates a release of parathyroid hormone (PTH), which maintains calcium homeostasis by 1) increasing bone mineral dissolution, thus releasing calcium and phosphorus, 2) increasing renal reabsorption of calcium and excretion of phosphorus, and 3) enhancing the gastrointestinal absorption of both calcium and phosphorus indirectly through its effects on the synthesis of 1,25(OH)2D (calcitriol). Leer más