Yearly Improvement in RKF and you can Emergency
Cox regression analyses with restricted cubic spline functions showed a significant association of annual change in renal CLurea with all-cause mortality in the minimally adjusted, case mix–adjusted, and fully adjusted models ( Figure 2 ); patients with faster CLurea decline showed higher risks of mortality. Case mix–adjusted HRs were 2.00 (95% CI, 1.55 to 2.59), 1.25 (95% CI, 1.16 to 1.35), 0.81 (95% CI, 0.73 to 0.91), and 0.61 (95% CI, 0.50 to 0.74) at ?6.0, ?3.0, ±0.0, and +3.0 ml/min per 1.73 m 2 per year of change in CLurea, respectively (reference: ?1.5 ml/min per 1.73 m 2 per year). These associations were robust against additional adjustment for baseline ultrafiltration rate and its annual change. Consistent trends were observed in subgroup analyses according to baseline CLurea ( Figure 3 ). Rapid CLurea decline (>3.0 ml/min per 1.73 m 2 per year) also showed a case mix–adjusted HR of 1.62 (95% CI, 1.27 to 2.07) for all-cause mortality. This association was not modified by baseline age (?65 or <65 years old), sex, race (white or nonwhite), diabetes, presence of congestive heart failure, hemoglobin (?11.5 or <11.5 g/dl), serum albumin (?3.6 or <3.6 g/dl), and serum phosphorus (?5.0 or <5.0 mg/dl; Ptelecommunications>0.20 for all) ( Figure 4 ).
Distributions and limited cubic splines evaluating the relationship off yearly transform within the residual kidney CL
urea with all-cause mortality among 6538 incident hemodialysis patients (2007–2010): (A) baseline renal CLurea adjustment model, (B) case mix adjustment model, (C) fully adjusted model, and (D) additional adjustment for baseline ultrafiltration rate (UFr) and its annual change on the fully adjusted model. Leer más